Protein Details: Chloride channel protein ClC-Kb

Protein ID

ICDB_Pro_0595

Protein Name

Chloride channel protein ClC-Kb

Gene Name

CLCNKB

Organism

Oryctolagus cuniculus (Rabbit)

Length

678 amino acids

AlphaFoldDB

AF-P51804-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

Sequence

MEELVGLREGSSGNPVALRELWSPCPRLRRGIRGGLEWLKQKLFRVGEDWYFLMTLGVLMALISYAMNFALGRVVRAHKWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPFSGGSGIPELKTILSGVVLENYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTKTIGEAENKSKQNEMLVAGAAVGVATVFAAPFSGVLFCIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFPVDVPFDLPEIFFFVLLGAICGVASCAYLYCQRTFLAFTKTNKLISKLMATSKPLYAALAATVLASITYPPGVGRFMASRLSMREHLDTLFDNHSWALLTRNSSPPWPAEPDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFLPIFIIGAAIGRLLGEALSVAFPEGIVAGGVINPIMPGGYALAGAAAFSGAVTHSISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIMVKKLPYLPWIRGRPINSHRVIVEHFMRRAISTLARDAALEQVVKVLTSTDEAEYPLVESTESQLLVGIVQRAQLVQALQAEAPARASGQQRCLQDILAGGCPTEPVTLTLSPETSLHQAHNLFELLNLRSLYVTSKGRAVVYVSWVERQHTGF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 121; /ligand="chloride" ; BINDING 259; /ligand="Ca(2+)"; BINDING 261; /ligand="Ca(2+)"; BINDING 278; /ligand="Ca(2+)"; BINDING 281; /ligand="Ca(2+)"; BINDING 426; /ligand="chloride"